Motif ID: TFAP2{A,C}.p2

Z-value: 1.997


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10412606,
chr6_-_10415438
0.523.5e-03Click!
TFAP2Cchr20_+_55204307-0.067.5e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224903933 3.907 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr3_-_124774735 3.241 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr15_+_41786055 3.100 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr3_+_51428720 2.802 RBM15B
RNA binding motif protein 15B
chr6_+_151561653 2.719 AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_28966419 2.667 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr5_-_1524022 2.621 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr19_-_41859830 2.592 NM_000660
TGFB1
transforming growth factor, beta 1
chr19_-_41859519 2.540 TGFB1
transforming growth factor, beta 1
chr20_+_6748744 2.514 NM_001200
BMP2
bone morphogenetic protein 2
chr8_+_86376130 2.435 NM_000067
CA2
carbonic anhydrase II
chr2_-_224903324 2.380 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr20_+_34203746 2.213 NM_003116
SPAG4
sperm associated antigen 4
chr19_-_41859332 2.200 TGFB1
transforming growth factor, beta 1
chr19_-_41859253 2.160 TGFB1
transforming growth factor, beta 1
chr19_-_41858948 2.124 TGFB1
transforming growth factor, beta 1
chr1_+_23037329 2.032 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr18_+_33877630 2.017 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_35491329 2.006 GRAMD1A
GRAM domain containing 1A
chr9_+_131183122 1.994 CERCAM
cerebral endothelial cell adhesion molecule
chr19_-_49865638 1.970 NM_003598
TEAD2
TEA domain family member 2
chr1_-_20812271 1.913 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_+_70759974 1.901 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_6321034 1.892 NM_207370
GPR153
G protein-coupled receptor 153
chr2_+_236403290 1.882 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr10_+_99400469 1.869 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr16_-_85784628 1.853 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr12_+_104850641 1.849 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr2_-_235405692 1.841 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr20_-_56284945 1.834 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_-_51472816 1.821 NM_002774
KLK6
kallikrein-related peptidase 6
chr20_+_56285213 1.810


chr10_-_43762366 1.768 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr2_-_72374919 1.755 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr17_-_76921076 1.745 TIMP2
TIMP metallopeptidase inhibitor 2
chr10_+_75545296 1.730 KIAA0913
KIAA0913
chr1_-_17307107 1.728 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr21_-_16437125 1.724 NM_003489
NRIP1
nuclear receptor interacting protein 1
chrX_+_152953751 1.719 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr20_+_1875825 1.701 NM_001040023
SIRPA
signal-regulatory protein alpha
chr9_-_94186140 1.690 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr19_+_2096792 1.678 NM_001031735
NM_001039846
IZUMO4

IZUMO family member 4

chr5_+_148520985 1.671 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr9_-_94185959 1.648 NFIL3
nuclear factor, interleukin 3 regulated
chr10_-_101380086 1.643 SLC25A28
solute carrier family 25, member 28
chr6_+_34204928 1.631 HMGA1
high mobility group AT-hook 1
chr9_+_131182690 1.604 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr11_+_43963809 1.598 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr14_-_75422466 1.575 NM_001207012
NM_002632
PGF

placental growth factor

chr9_-_19127462 1.565 PLIN2
perilipin 2
chr2_+_70142303 1.558 MXD1
MAX dimerization protein 1
chr7_-_129251465 1.553


chr14_-_77787023 1.553 NM_013382
POMT2
protein-O-mannosyltransferase 2
chr15_+_67358194 1.550 NM_005902
SMAD3
SMAD family member 3
chrX_+_68725077 1.529 NM_015686
FAM155B
family with sequence similarity 155, member B
chr15_+_67358161 1.527 SMAD3
SMAD family member 3
chr10_-_101380217 1.506 NM_031212
SLC25A28
solute carrier family 25, member 28
chr6_+_41040891 1.502 NFYA
nuclear transcription factor Y, alpha
chr10_-_101380160 1.494 SLC25A28
solute carrier family 25, member 28
chr12_-_121734543 1.491 NM_172226
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr20_-_60942300 1.488 NM_005560
LAMA5
laminin, alpha 5
chr16_-_89007605 1.483 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_+_50192847 1.474 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr1_-_204120909 1.470 ETNK2
ethanolamine kinase 2
chr22_+_33197744 1.450 TIMP3
TIMP metallopeptidase inhibitor 3
chr12_+_53491448 1.442 IGFBP6
insulin-like growth factor binding protein 6
chr6_+_43738757 1.430 VEGFA
vascular endothelial growth factor A
chr9_+_35605275 1.416 NM_006285
TESK1
testis-specific kinase 1
chr10_+_75936546 1.412 ADK
adenosine kinase
chr13_-_20806533 1.407 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr5_+_92920592 1.402 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr8_-_48650683 1.400 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_46768852 1.399 LRRC41
leucine rich repeat containing 41
chr19_+_10828813 1.397 DNM2
dynamin 2
chr2_+_239756672 1.390 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr4_-_174450529 1.380 HAND2
heart and neural crest derivatives expressed 2
chr9_+_128509616 1.340 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr1_-_6545521 1.339 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_-_1513187 1.336 NM_213604
ADAMTSL5
ADAMTS-like 5
chr17_-_74707000 1.333 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr6_+_34205369 1.331 HMGA1
high mobility group AT-hook 1
chr11_-_62314199 1.325 AHNAK
AHNAK nucleoprotein
chr9_+_124461365 1.319 DAB2IP
DAB2 interacting protein
chr19_+_2096930 1.308 IZUMO4
IZUMO family member 4
chr19_-_15311773 1.297 NM_000435
NOTCH3
notch 3
chr7_-_143059696 1.294 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr22_+_31487315 1.287 SMTN
smoothelin
chr15_-_48937068 1.282 FBN1
fibrillin 1
chr11_-_61062534 1.278 VWCE
von Willebrand factor C and EGF domains
chr21_-_28217272 1.274 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_173292344 1.269 ITGA6
integrin, alpha 6
chr12_+_27485767 1.267 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr17_+_74380676 1.245 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr12_-_124018428 1.242 RILPL1
Rab interacting lysosomal protein-like 1
chr12_-_25348031 1.236 NM_001082972
NM_001082973
NM_001204101
NM_001204102
NM_018272
CASC1




cancer susceptibility candidate 1




chr14_+_65171243 1.227 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_+_31456879 1.223 NM_014600
EHD3
EH-domain containing 3
chr3_-_48885028 1.219 PRKAR2A
protein kinase, cAMP-dependent, regulatory, type II, alpha
chr17_-_6735007 1.217 NM_053285
TEKT1
tektin 1
chr20_-_43280359 1.217 NM_000022
ADA
adenosine deaminase
chr6_+_34204690 1.216 HMGA1
high mobility group AT-hook 1
chr12_-_25801487 1.215 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr19_+_7580987 1.212 NM_018083
ZNF358
zinc finger protein 358
chr8_-_124553448 1.211 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr20_+_1874943 1.210 SIRPA
signal-regulatory protein alpha
chr20_+_1875132 1.206 SIRPA
signal-regulatory protein alpha
chr7_-_50861114 1.203 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr8_-_10587942 1.199 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr2_+_85980600 1.198 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr6_-_42946940 1.193 NM_000287
PEX6
peroxisomal biogenesis factor 6
chr6_-_42946887 1.191 PEX6
peroxisomal biogenesis factor 6
chr22_+_31489343 1.188 SMTN
smoothelin
chr8_+_22022644 1.186 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr10_-_100027943 1.184 NM_032211
LOXL4
lysyl oxidase-like 4
chr2_+_236402948 1.179 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr21_-_28217692 1.177 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_106682111 1.175 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr1_-_204121144 1.170 NM_018208
ETNK2
ethanolamine kinase 2
chr17_+_48423382 1.155 NM_022167
XYLT2
xylosyltransferase II
chr18_-_48723689 1.155 MEX3C
mex-3 homolog C (C. elegans)
chrX_-_132092224 1.153 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr3_+_171758289 1.149 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr19_+_10828772 1.144 DNM2
dynamin 2
chr12_-_96184510 1.143 NM_021229
NTN4
netrin 4
chr11_-_128392061 1.137 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr5_-_176831183 1.131 F12
coagulation factor XII (Hageman factor)
chr2_+_64681610 1.127 LGALSL
lectin, galactoside-binding-like
chr14_+_105886253 1.127 MTA1
metastasis associated 1
chr20_-_590909 1.127 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr8_-_21966812 1.126 NM_024815
NUDT18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
chr1_-_162838550 1.124 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr20_+_1876006 1.123 SIRPA
signal-regulatory protein alpha
chr9_+_35605339 1.122 TESK1
testis-specific kinase 1
chr22_-_26986065 1.120 TPST2
tyrosylprotein sulfotransferase 2
chr6_+_34205029 1.120 HMGA1
high mobility group AT-hook 1
chr1_-_75139421 1.110 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr17_+_70117177 1.110 SOX9
SRY (sex determining region Y)-box 9
chr1_-_120612175 1.101 NOTCH2
notch 2
chr19_+_54926721 1.097 TTYH1
tweety homolog 1 (Drosophila)
chr20_+_1874779 1.092 NM_001040022
SIRPA
signal-regulatory protein alpha
chr18_+_56338783 1.091 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr22_-_26986041 1.086 TPST2
tyrosylprotein sulfotransferase 2
chr6_+_163149001 1.085 NM_001080379
PACRG
PARK2 co-regulated
chr6_+_151187310 1.084 NM_001242768
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr21_-_35883570 1.083 NM_000219
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr22_+_33197678 1.079 TIMP3
TIMP metallopeptidase inhibitor 3
chr17_+_7211260 1.078 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr7_-_98741605 1.078 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr7_-_130353561 1.069 COPG2
coatomer protein complex, subunit gamma 2
chr22_-_19512001 1.068 CLDN5
claudin 5
chr19_+_10828763 1.064 DNM2
dynamin 2
chr6_+_43612766 1.061 NM_001193341
NM_152732
RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr6_+_151561508 1.060 AKAP12
A kinase (PRKA) anchor protein 12
chr18_+_56530677 1.060 ZNF532
zinc finger protein 532
chr12_-_122231554 1.056 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr6_+_43738177 1.056 VEGFA
vascular endothelial growth factor A
chr9_+_35605449 1.054 TESK1
testis-specific kinase 1
chr12_+_96588254 1.052 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr22_+_50919970 1.052 NM_024866
NM_001253845
ADM2

adrenomedullin 2

chr10_-_25241504 1.051 NM_020200
PRTFDC1
phosphoribosyl transferase domain containing 1
chr6_+_4079439 1.051 NM_001085401
C6orf201
chromosome 6 open reading frame 201
chr7_+_150783771 1.042 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr16_+_68679198 1.040 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_+_11784355 1.033 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr9_+_34458810 1.032 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr6_+_41606193 1.032 NM_005586
MDFI
MyoD family inhibitor
chr1_-_46768821 1.027 LRRC41
leucine rich repeat containing 41
chr7_-_130353579 1.027 NM_012133
COPG2
coatomer protein complex, subunit gamma 2
chr1_-_109656478 1.026 NM_001122961
C1orf194
chromosome 1 open reading frame 194
chr19_-_1512997 1.021 ADAMTSL5
ADAMTS-like 5
chr7_-_98741375 1.017 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr2_+_173292306 1.016 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr16_-_58231641 1.012 NM_001896
CSNK2A2
casein kinase 2, alpha prime polypeptide
chr9_-_38069082 1.010 SHB
Src homology 2 domain containing adaptor protein B
chr7_-_50860665 1.010 GRB10
growth factor receptor-bound protein 10
chr12_-_96184346 1.007 NTN4
netrin 4
chr8_+_17013799 1.007 NM_016353
ZDHHC2
zinc finger, DHHC-type containing 2
chr5_-_134369841 1.006 NM_002653
PITX1
paired-like homeodomain 1
chr8_-_131455833 0.999 NM_001247996
NM_018482
ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

chr15_-_83953465 0.994 NM_001717
BNC1
basonuclin 1
chr20_-_56285576 0.989 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chrX_+_135229536 0.988 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr3_-_195635879 0.988 NM_005781
TNK2
tyrosine kinase, non-receptor, 2
chr19_-_41859767 0.986 TGFB1
transforming growth factor, beta 1
chr2_-_220408264 0.982 NM_024536
CHPF
chondroitin polymerizing factor
chr10_+_23216953 0.981 NM_173081
ARMC3
armadillo repeat containing 3
chr2_-_1748285 0.980 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr12_-_51611476 0.978 POU6F1
POU class 6 homeobox 1
chr11_-_65640199 0.978 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr10_-_17659365 0.977 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr5_-_11904127 0.973 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr12_+_104850762 0.969 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_-_197686837 0.969 NM_032263
IQCG
IQ motif containing G
chr1_+_230202928 0.966 NM_004481
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr19_+_54926604 0.966 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr20_+_1875534 0.964 SIRPA
signal-regulatory protein alpha
chr15_+_66995414 0.964 SMAD6
SMAD family member 6
chr2_-_86116016 0.962 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr18_-_12657736 0.962 SPIRE1
spire homolog 1 (Drosophila)
chr2_-_25564745 0.960 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 3.31e-38 GO:0009987 cellular process
1.22 3.58e-24 GO:0071840 cellular component organization or biogenesis
1.22 3.17e-23 GO:0016043 cellular component organization
1.14 6.13e-21 GO:0044237 cellular metabolic process
1.18 7.11e-21 GO:0044260 cellular macromolecule metabolic process
1.22 6.53e-18 GO:0071841 cellular component organization or biogenesis at cellular level
1.22 6.66e-17 GO:0071842 cellular component organization at cellular level
1.11 2.48e-15 GO:0008152 metabolic process
1.12 7.03e-15 GO:0044238 primary metabolic process
1.14 3.71e-14 GO:0043170 macromolecule metabolic process
1.10 6.89e-14 GO:0065007 biological regulation
1.10 1.22e-13 GO:0050789 regulation of biological process
1.10 9.32e-13 GO:0050794 regulation of cellular process
1.16 1.34e-11 GO:0051179 localization
1.22 2.95e-10 GO:0006464 protein modification process
1.38 3.86e-10 GO:0030030 cell projection organization
1.23 5.80e-10 GO:0006996 organelle organization
1.16 9.23e-10 GO:0034641 cellular nitrogen compound metabolic process
1.24 1.06e-09 GO:0007399 nervous system development
1.15 1.79e-09 GO:0006807 nitrogen compound metabolic process
1.20 1.90e-09 GO:0043412 macromolecule modification
1.41 3.19e-09 GO:0007010 cytoskeleton organization
1.19 3.77e-09 GO:0048523 negative regulation of cellular process
1.16 3.80e-09 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 5.93e-09 GO:0007049 cell cycle
1.22 8.25e-09 GO:0023051 regulation of signaling
1.17 1.45e-08 GO:0044267 cellular protein metabolic process
1.28 1.49e-08 GO:0006793 phosphorus metabolic process
1.28 1.49e-08 GO:0006796 phosphate metabolic process
1.29 2.09e-08 GO:0022008 neurogenesis
1.35 3.18e-08 GO:0032989 cellular component morphogenesis
1.15 3.60e-08 GO:0051234 establishment of localization
1.28 6.37e-08 GO:0048468 cell development
1.35 1.13e-07 GO:0000902 cell morphogenesis
1.29 1.63e-07 GO:0048699 generation of neurons
1.16 2.79e-07 GO:0048519 negative regulation of biological process
1.17 3.92e-07 GO:0048869 cellular developmental process
1.14 4.24e-07 GO:0006810 transport
1.23 4.39e-07 GO:0051641 cellular localization
1.21 4.80e-07 GO:0009966 regulation of signal transduction
1.31 6.65e-07 GO:0030182 neuron differentiation
1.36 1.09e-06 GO:0000904 cell morphogenesis involved in differentiation
1.17 1.09e-06 GO:0090304 nucleic acid metabolic process
1.28 1.88e-06 GO:0022402 cell cycle process
1.35 2.48e-06 GO:0032990 cell part morphogenesis
1.35 2.61e-06 GO:0048858 cell projection morphogenesis
1.33 2.65e-06 GO:0048666 neuron development
1.17 3.11e-06 GO:0030154 cell differentiation
1.12 3.78e-06 GO:0032502 developmental process
1.24 3.80e-06 GO:0022607 cellular component assembly
1.15 4.70e-06 GO:0048522 positive regulation of cellular process
1.22 5.08e-06 GO:0044085 cellular component biogenesis
1.48 8.17e-06 GO:0030036 actin cytoskeleton organization
1.26 9.86e-06 GO:0016310 phosphorylation
1.36 1.28e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.28 1.49e-05 GO:0006468 protein phosphorylation
1.31 1.61e-05 GO:0000278 mitotic cell cycle
1.12 2.41e-05 GO:0031323 regulation of cellular metabolic process
1.11 2.50e-05 GO:0019222 regulation of metabolic process
1.43 2.63e-05 GO:0030029 actin filament-based process
1.25 3.94e-05 GO:0051128 regulation of cellular component organization
1.33 5.19e-05 GO:0031175 neuron projection development
1.34 5.23e-05 GO:0048812 neuron projection morphogenesis
1.22 6.25e-05 GO:0032268 regulation of cellular protein metabolic process
1.11 7.96e-05 GO:0080090 regulation of primary metabolic process
1.21 9.22e-05 GO:0051649 establishment of localization in cell
1.11 1.14e-04 GO:0023052 signaling
1.24 1.14e-04 GO:0016265 death
1.14 1.24e-04 GO:0044249 cellular biosynthetic process
1.38 1.63e-04 GO:0032535 regulation of cellular component size
1.13 1.79e-04 GO:0048518 positive regulation of biological process
1.23 1.86e-04 GO:0008219 cell death
1.12 1.87e-04 GO:0019538 protein metabolic process
1.25 1.96e-04 GO:0046907 intracellular transport
1.16 2.05e-04 GO:0048583 regulation of response to stimulus
1.21 2.08e-04 GO:0051246 regulation of protein metabolic process
1.36 2.10e-04 GO:0090066 regulation of anatomical structure size
1.11 2.73e-04 GO:0007275 multicellular organismal development
1.33 2.92e-04 GO:0007409 axonogenesis
1.12 2.98e-04 GO:0048856 anatomical structure development
1.36 3.38e-04 GO:0051301 cell division
1.25 3.76e-04 GO:0071844 cellular component assembly at cellular level
1.47 3.79e-04 GO:0044087 regulation of cellular component biogenesis
1.17 3.92e-04 GO:0009653 anatomical structure morphogenesis
1.32 4.55e-04 GO:0061024 membrane organization
1.61 4.64e-04 GO:0007265 Ras protein signal transduction
1.26 5.24e-04 GO:0022403 cell cycle phase
1.13 6.54e-04 GO:0009058 biosynthetic process
1.11 6.91e-04 GO:0060255 regulation of macromolecule metabolic process
1.31 8.02e-04 GO:0016044 cellular membrane organization
1.32 1.37e-03 GO:0009968 negative regulation of signal transduction
1.25 1.61e-03 GO:0009719 response to endogenous stimulus
1.20 1.75e-03 GO:0032879 regulation of localization
1.10 2.30e-03 GO:0007165 signal transduction
1.30 2.51e-03 GO:0010648 negative regulation of cell communication
1.19 2.61e-03 GO:0010646 regulation of cell communication
1.15 2.71e-03 GO:0016070 RNA metabolic process
1.23 2.76e-03 GO:0012501 programmed cell death
1.11 3.10e-03 GO:0048731 system development
1.30 3.29e-03 GO:0023057 negative regulation of signaling
1.18 3.88e-03 GO:0031325 positive regulation of cellular metabolic process
1.25 4.21e-03 GO:0009725 response to hormone stimulus
1.35 4.77e-03 GO:0048285 organelle fission
1.23 4.95e-03 GO:0006915 apoptosis
1.17 5.16e-03 GO:0009893 positive regulation of metabolic process
1.15 5.55e-03 GO:0034645 cellular macromolecule biosynthetic process
1.35 6.19e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.35 6.50e-03 GO:0000087 M phase of mitotic cell cycle
1.14 6.83e-03 GO:0010467 gene expression
1.35 7.17e-03 GO:0000280 nuclear division
1.35 7.17e-03 GO:0007067 mitosis
1.49 7.71e-03 GO:0034330 cell junction organization
1.33 8.21e-03 GO:0007411 axon guidance
1.09 8.55e-03 GO:0051716 cellular response to stimulus
1.51 1.03e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.14 1.19e-02 GO:0009059 macromolecule biosynthetic process
1.38 1.23e-02 GO:0007507 heart development
1.39 1.30e-02 GO:0051129 negative regulation of cellular component organization
1.27 1.36e-02 GO:0070271 protein complex biogenesis
1.34 1.36e-02 GO:0051270 regulation of cellular component movement
1.16 1.46e-02 GO:0033036 macromolecule localization
1.20 1.52e-02 GO:0033554 cellular response to stress
1.50 1.61e-02 GO:0034329 cell junction assembly
1.21 1.62e-02 GO:0031399 regulation of protein modification process
1.26 1.80e-02 GO:0006461 protein complex assembly
1.23 1.82e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.16 1.92e-02 GO:0035556 intracellular signal transduction
1.19 2.08e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.18 2.14e-02 GO:0008104 protein localization
1.12 2.15e-02 GO:0065008 regulation of biological quality
1.19 2.19e-02 GO:0006351 transcription, DNA-dependent
1.17 2.27e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.19 2.91e-02 GO:0050793 regulation of developmental process
1.29 3.01e-02 GO:0009792 embryo development ending in birth or egg hatching
1.18 3.30e-02 GO:0009892 negative regulation of metabolic process
1.35 3.50e-02 GO:0008361 regulation of cell size
1.25 3.68e-02 GO:0048585 negative regulation of response to stimulus
1.45 3.84e-02 GO:0000226 microtubule cytoskeleton organization
1.22 3.87e-02 GO:0051726 regulation of cell cycle
1.73 4.00e-02 GO:0007163 establishment or maintenance of cell polarity
1.19 4.03e-02 GO:0031324 negative regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 6.60e-37 GO:0044424 intracellular part
1.09 7.11e-37 GO:0005622 intracellular
1.13 3.75e-35 GO:0005737 cytoplasm
1.11 3.09e-26 GO:0043227 membrane-bounded organelle
1.11 4.89e-26 GO:0043231 intracellular membrane-bounded organelle
1.10 6.96e-25 GO:0043226 organelle
1.10 1.17e-24 GO:0043229 intracellular organelle
1.14 4.77e-23 GO:0044444 cytoplasmic part
1.13 3.62e-16 GO:0044422 organelle part
1.13 3.78e-16 GO:0044446 intracellular organelle part
1.13 1.22e-15 GO:0005634 nucleus
1.23 8.58e-15 GO:0005829 cytosol
1.19 4.71e-11 GO:0044428 nuclear part
1.20 5.27e-10 GO:0031981 nuclear lumen
1.03 1.27e-09 GO:0044464 cell part
1.03 1.45e-09 GO:0005623 cell
1.64 1.45e-09 GO:0031252 cell leading edge
1.17 5.65e-09 GO:0070013 intracellular organelle lumen
1.17 7.47e-09 GO:0031974 membrane-enclosed lumen
1.28 1.82e-08 GO:0042995 cell projection
1.16 4.38e-08 GO:0043233 organelle lumen
1.22 1.08e-07 GO:0005654 nucleoplasm
1.19 1.61e-07 GO:0012505 endomembrane system
1.62 2.69e-07 GO:0005912 adherens junction
1.13 1.04e-06 GO:0043234 protein complex
1.30 2.71e-06 GO:0030054 cell junction
1.56 3.15e-06 GO:0070161 anchoring junction
1.15 1.73e-05 GO:0031090 organelle membrane
1.65 6.41e-05 GO:0005925 focal adhesion
1.38 1.05e-04 GO:0015629 actin cytoskeleton
1.42 1.15e-04 GO:0016323 basolateral plasma membrane
1.10 1.17e-04 GO:0032991 macromolecular complex
1.68 1.20e-04 GO:0001726 ruffle
1.62 1.37e-04 GO:0005924 cell-substrate adherens junction
1.61 1.57e-04 GO:0030055 cell-substrate junction
1.24 4.04e-04 GO:0015630 microtubule cytoskeleton
1.66 5.15e-04 GO:0030027 lamellipodium
1.19 6.64e-04 GO:0005794 Golgi apparatus
1.33 7.23e-04 GO:0005815 microtubule organizing center
1.12 1.08e-03 GO:0044459 plasma membrane part
1.11 1.09e-03 GO:0043228 non-membrane-bounded organelle
1.11 1.09e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.72 1.71e-03 GO:0031256 leading edge membrane
1.42 2.49e-03 GO:0005819 spindle
1.14 3.98e-03 GO:0005856 cytoskeleton
1.23 6.85e-03 GO:0005694 chromosome
1.27 7.77e-03 GO:0043005 neuron projection
1.22 8.78e-03 GO:0044431 Golgi apparatus part
1.20 1.02e-02 GO:0031967 organelle envelope
1.20 1.17e-02 GO:0031975 envelope
1.38 2.72e-02 GO:0030424 axon
1.35 2.93e-02 GO:0030135 coated vesicle
1.25 3.28e-02 GO:0044463 cell projection part
1.17 4.23e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 7.47e-34 GO:0005515 protein binding
1.08 8.53e-27 GO:0005488 binding
1.18 3.60e-10 GO:0000166 nucleotide binding
1.30 1.07e-08 GO:0016301 kinase activity
1.31 3.21e-08 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.19 8.15e-08 GO:0016740 transferase activity
1.18 1.12e-07 GO:0017076 purine nucleotide binding
1.26 1.44e-07 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 1.88e-07 GO:0032553 ribonucleotide binding
1.18 1.88e-07 GO:0032555 purine ribonucleotide binding
1.38 2.37e-07 GO:0019904 protein domain specific binding
1.17 5.29e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.28 6.43e-07 GO:0019899 enzyme binding
1.18 3.47e-06 GO:0030554 adenyl nucleotide binding
1.31 7.27e-06 GO:0008092 cytoskeletal protein binding
1.18 7.78e-06 GO:0032559 adenyl ribonucleotide binding
1.17 3.05e-05 GO:0005524 ATP binding
1.28 3.07e-05 GO:0004672 protein kinase activity
1.31 1.56e-04 GO:0004674 protein serine/threonine kinase activity
1.08 3.72e-04 GO:0003824 catalytic activity
1.90 9.43e-04 GO:0008013 beta-catenin binding
1.28 1.67e-03 GO:0030695 GTPase regulator activity
1.32 2.86e-03 GO:0003779 actin binding
1.27 3.46e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.21 3.65e-03 GO:0042802 identical protein binding
1.19 3.91e-03 GO:0030234 enzyme regulator activity
1.45 5.20e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.31 1.71e-02 GO:0005083 small GTPase regulator activity
1.39 4.27e-02 GO:0000287 magnesium ion binding