Motif ID: TFAP2{A,C}.p2

Z-value: 1.997


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10412606,
chr6_-_10415438
0.523.5e-03Click!
TFAP2Cchr20_+_55204307-0.067.5e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_224903933 3.907 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr3_-_124774735 3.241 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr15_+_41786055 3.100 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr3_+_51428720 2.802 RBM15B
RNA binding motif protein 15B
chr6_+_151561653 2.719 AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_28966419 2.667 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr5_-_1524022 2.621 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr19_-_41859830 2.592 NM_000660
TGFB1
transforming growth factor, beta 1
chr19_-_41859519 2.540 TGFB1
transforming growth factor, beta 1
chr20_+_6748744 2.514 NM_001200
BMP2
bone morphogenetic protein 2
chr8_+_86376130 2.435 NM_000067
CA2
carbonic anhydrase II
chr2_-_224903324 2.380 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr20_+_34203746 2.213 NM_003116
SPAG4
sperm associated antigen 4
chr19_-_41859332 2.200 TGFB1
transforming growth factor, beta 1
chr19_-_41859253 2.160 TGFB1
transforming growth factor, beta 1
chr19_-_41858948 2.124 TGFB1
transforming growth factor, beta 1
chr1_+_23037329 2.032 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr18_+_33877630 2.017 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_35491329 2.006 GRAMD1A
GRAM domain containing 1A
chr9_+_131183122 1.994 CERCAM
cerebral endothelial cell adhesion molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 141 entries
enrichment   p-value GO term description
1.73 4.00e-02 GO:0007163 establishment or maintenance of cell polarity
1.61 4.64e-04 GO:0007265 Ras protein signal transduction
1.51 1.03e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.50 1.61e-02 GO:0034329 cell junction assembly
1.49 7.71e-03 GO:0034330 cell junction organization
1.48 8.17e-06 GO:0030036 actin cytoskeleton organization
1.47 3.79e-04 GO:0044087 regulation of cellular component biogenesis
1.45 3.84e-02 GO:0000226 microtubule cytoskeleton organization
1.43 2.63e-05 GO:0030029 actin filament-based process
1.41 3.19e-09 GO:0007010 cytoskeleton organization
1.39 1.30e-02 GO:0051129 negative regulation of cellular component organization
1.38 3.86e-10 GO:0030030 cell projection organization
1.38 1.63e-04 GO:0032535 regulation of cellular component size
1.38 1.23e-02 GO:0007507 heart development
1.36 1.09e-06 GO:0000904 cell morphogenesis involved in differentiation
1.36 1.28e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.36 2.10e-04 GO:0090066 regulation of anatomical structure size
1.36 3.38e-04 GO:0051301 cell division
1.35 3.18e-08 GO:0032989 cellular component morphogenesis
1.35 1.13e-07 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
1.72 1.71e-03 GO:0031256 leading edge membrane
1.68 1.20e-04 GO:0001726 ruffle
1.66 5.15e-04 GO:0030027 lamellipodium
1.65 6.41e-05 GO:0005925 focal adhesion
1.64 1.45e-09 GO:0031252 cell leading edge
1.62 2.69e-07 GO:0005912 adherens junction
1.62 1.37e-04 GO:0005924 cell-substrate adherens junction
1.61 1.57e-04 GO:0030055 cell-substrate junction
1.56 3.15e-06 GO:0070161 anchoring junction
1.42 1.15e-04 GO:0016323 basolateral plasma membrane
1.42 2.49e-03 GO:0005819 spindle
1.38 1.05e-04 GO:0015629 actin cytoskeleton
1.38 2.72e-02 GO:0030424 axon
1.35 2.93e-02 GO:0030135 coated vesicle
1.33 7.23e-04 GO:0005815 microtubule organizing center
1.30 2.71e-06 GO:0030054 cell junction
1.28 1.82e-08 GO:0042995 cell projection
1.27 7.77e-03 GO:0043005 neuron projection
1.25 3.28e-02 GO:0044463 cell projection part
1.24 4.04e-04 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
1.90 9.43e-04 GO:0008013 beta-catenin binding
1.45 5.20e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.39 4.27e-02 GO:0000287 magnesium ion binding
1.38 2.37e-07 GO:0019904 protein domain specific binding
1.32 2.86e-03 GO:0003779 actin binding
1.31 3.21e-08 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.31 7.27e-06 GO:0008092 cytoskeletal protein binding
1.31 1.56e-04 GO:0004674 protein serine/threonine kinase activity
1.31 1.71e-02 GO:0005083 small GTPase regulator activity
1.30 1.07e-08 GO:0016301 kinase activity
1.28 6.43e-07 GO:0019899 enzyme binding
1.28 3.07e-05 GO:0004672 protein kinase activity
1.28 1.67e-03 GO:0030695 GTPase regulator activity
1.27 3.46e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.26 1.44e-07 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.21 3.65e-03 GO:0042802 identical protein binding
1.19 8.15e-08 GO:0016740 transferase activity
1.19 3.91e-03 GO:0030234 enzyme regulator activity
1.18 3.60e-10 GO:0000166 nucleotide binding
1.18 1.12e-07 GO:0017076 purine nucleotide binding